Below is a partial list of the research support in VRSANO’s patent which has informed its design:

Psychological influence on medical treatments:

Abbott, J., Abbott, P. (1995). Psychological and cardiovascular predictors of anaesthesia induction, operative and postoperative complications in minor gynecological surgery. British Journal of Clinical Psychology, 34, 613-625.

Ben Eliyahu, S. Page, G. G., Yirmiya, R., Shakhar, G. (1999). Evidence that stress and surgical interventions promote tumor development by suppressing natural killer cell activity. International Journal of Cancer, 80(6), 880-888.

Ben Eliyahu, S. (2003). The promotion of tumor metastasis by surgery and stress: immunological basis and implications for psychoneuroimmunology. Brain, Behavior and Immunity, February; 17 Suppl 1:S27-36.

Contrada, R. J., Leventhal, E. A., & Anderson, J. R. (1994). Psychological preparation for surgery: Marshaling individual and social resources to optimize self-regulation. In S. Maes, H. Leventhal, & M. Johnson (Eds.), International Review of Health Psychology, Vol. 3, 219-266. New York: Wiley.

Devine, E. (1992). Effects of psychoeducational care for adult surgical patients: A meta-analysis of 191 studies. Patient Education and Counseling, 19, 129-142.

Egbert, L. D., Battit, G. E., Welch, C. E., & Barlett, M. K. (1964). Reduction of postoperative pain by encouragement and instruction of patients. New England Journal of Medicine, 270, 825-827.

Gil, K. M. (1984). Coping effectively with invasive medical procedures: A descriptive model. Clinical Psychology Review, 4, 339-362.

Greene, P. G., Zeichner, A., Roberts, N. L., Caltahan, E. J., & Granados, J. L. (1989). Preparation for cesarean delivery: A mutticompouent analysis of treatment outcome. Journal of Consulting and Clinical Psychology, 57, 484-487.Lang E. V., Benotsch E. G., Fick L. J.,

Eccleston, C., Crombez, G. (1999). Pain demands attention: a cognitive-affective model of the interruptive function of pain. Psychological Bulletin, 125:356-366.

Johnston, M., Vogele, C. (1993). Benefits of psychological preparation for surgery: A meta-analysis. Annals of Behavioral Medicine, 15, 245-256.

Kiecolt-Glaser, J. K., Page, G., Marucha, P. T., MacCallum, R. C., Glaser , R. (1998); Psychological Influences on Surgical Recovery. Perspectives From Psychoneuroimmunology. November; American Psychologist.

Lutgendorf S., Berbaum M. L., Berbaum K. S., Logan H., Spiegel D. (2000). Adjunctive non-pharmacological analgesia for invasive medical procedures: a randomised trial. 355(9214):1486-1490

Liu, R., Barry, J. E. S., & Weinman, J. (1994). Effect of background stress on postoperative recovery. Anaesthesia, 49, 382-386.

Meyerhoff, J. L., Oleshansky, M. A., Kalogeras, K. T., Mougey, E. H., Chrousus, G. P., Graner, L. G. (1990). Neuroendocrine responses to emotional stress: possible interactions between circulating factors and anterior pituitary hormone release. Circulating Regulatory Factors and Neuroendocrine Function, Advantages in Experimental Medicine and Biology. 274, 91-111.

Mumford, E., Schlesinger, H. J., Glass, G. V. (1982). The effect of psychological intervention on recovery from surgery and heart attacks: An analysis of the literature. American Journal of Public Health, 72, 141-151.

Neeman, E., Ben-Eliyahu, S. (2013). Surgery and stress promote cancer metastasis: new outlooks on perioperative mediating mechanisms and immune involvement. Brain, Behavior and Immunity. Suppl:S, 32-40.

Virtual Reality in Healthcare:

Flores A., Hoffman H. G., Russell W., (2008). Longer, multiple virtual reality pain distraction treatments of Hispanic and Caucasian children with large severe burns. CyberTherapy Conference. San Diego, Calif.

Hoffman, H. G., Chambers, G. T., Meyer III, W. J., Arceneaux, L. L., Russel, W. J., Seibel, E. J., Richards, T. L., Sharar, S. R., Patterson, D. R. (2011). Virtual reality as an adjunctive non-pharmacologic analgesic for acute burn pain during medical procedures. Annals of Behavioral Medicine, 41(2), 183-191.

Hoffman H. G., Meyer III W. J., Ramirez M., Roberts L., Seibel E. J., Atzori B., Sharar S. R., and Patterson D. R. (2014). Feasibility of articulated arm mounted oculus rift virtual reality goggles for adjunctive pain control during occupational therapy in pediatric burn patients. Cyberpsychology, Behavior, and Social Networking, 17(6), 397-401.

Hoffman H. G., Richards T. L., Bills A. R., (2006). Using FMRI to study the neural correlates of virtual reality analgesia. CNS Spectrums 11:45-51

Maani, C., Hoffman, H. G., DeSocio, P. A., (2008). Pain control during wound care for combat-related burn injuries using custom articulated arm mounted virtual reality goggles. Journal of CyberTherapy and Rehabilitation, 1:193-198.

Patterson, D. R.; Hoffman, H. G.; Palacios, A. Garcia; Jensen, M. J. (2006). Analgesic effects of posthypnotic suggestions and virtual reality distraction on thermal pain. Journal of Abnormal Psychology, Vol 115(4). 834-841.

Sharar, S. R., Carrougher, G. J., Nakamura, D., Hoffman, H. G., Blough, D. K., Patterson, D. R. (2007). Factors influencing the efficacy of virtual reality distraction analgesia during postburn physical therapy: preliminary results from 3 ongoing studies. Archives of Physical Medicine & Rehabilitation, 88(12), s43-s49.

Sulea, C., Soomro, A., Boyd, C., Wiederhold, B. K. (2014). Pain management in virtual reality: a comprehensive research chart. Cyberpsychology, Behavior, and Social Networking, 17(6), 402-413.

Clinical Hypnosis in Healthcare:

Butler, L. D., Symons, B. K., Henderson, S. L., Shortliffe, L. D., Spiegel, D. (2005). Hypnosis reduces distress and duration of an invasive medical procedure for children. Pediatrics, 115(1), e77-e85

Calipel, S., Lucaspolomeni, M., Wodey, E., & Ecoffey, C. (2005). Premedication in children: Hypnosis versus midazolam. Pediatric Anesthesia, 15(4), 275-281.

Colgan S. M., Faragher E. B., Whorwell P. J. (1988). Controlled trial of hypnotherapy in relapse prevention of duodenal ulceration. Lancet. 1(8598):1299-1300

Cowan, G. S., Jr., et al. (2001). Assessment of the effects of a taped cognitive behavior message on postoperative complications (therapeutic suggestions under anesthesia). Obesity Surgery, 11(5), 589-593

Ewin, D. (1986). The effect of hypnosis and mind set on burns. Psychiatric Annals, 16, 115-118. Experimental Hypnosis. 56(4): 451-462.

Ginandes, C., Brooks P., Sando W., Jones C., Aker J. (2003). Can medical hypnosis accelerate post-surgical wound healing? Results of a clinical trial. American Journal of Clinical Hypnosis, 45(4), 333-351.

Ginandes, C. & Rosenthal, D. I. (1999). Using hypnosis to accelerate the healing of bone fractures: A randomized controlled pilot study. Alternative Therapies in Health and Medicine, 5(2), 67-75.

Gruzelier, J. (1998). a working model of the neurophysiology of hypnosis: a review of evidence. Contemporary Hypnosis, 15(1), 3-21

Kirjanen, S. (2012). Brain activity during pain relief using hypnosis and placebo treatments: a literature review. Journal of European Psychology Students. Vol 3.

Lang E. V., Berbaum K. S., Faintuch S., Hatsiopoulou O., Halsey N., Li X., Berbaum M. L., Laser E., Baum J. (2006). Adjunctive self-hypnotic relaxation for outpatient medical procedures: a prospective randomized trial with women undergoing large core breast biopsy. Pain. 126(1-3):155-164

Lang E. V., Berbaum K. S., Faintuch S., Hatsiopoulou O., Halsey N., Li X., Berbaum M. L., Laser E., Baum J. (2006). Adjunctive self-hypnotic relaxation for outpatient medical procedures: a prospective randomized trial with women undergoing large core breast biopsy. Pain. 126(1-3):155-164

Lobe, T. E. (2006). Perioperative hypnosis reduces hospitalization in patients undergoing the Nuss procedure for pectus excavatum. Journal of Laparoendoscopic & Advanced Surgical Techniques, 16(6), 639-642.

Lynn, S. J., Kirsch I., Barabasz A., Cardeña E., Patterson D. (2000). Hypnosis as an empirically supported clinical intervention: The state of the evidence and a look to the future. International Journal of Clinical and Experimental Hypnosis, 48(2), 239-59.

Mehmet, C. O. (2000). About self-hypnosis and coronary artery bypass surgery. Journal of Cardiothoracic Surgery (Torino), 41(2), 335-336.

Montgomery G. H., Bovbjerg D. H., Schnur J. B., David D., Goldfarb A., Weltz C. R., Schechter C., Graff-Zivin J., Tatrow K., Price D. D., Silverstein J. H. (2007). A randomized clinical trial of a brief hypnosis intervention to control side effects in breast surgery patients. J Natl Cancer Inst. 99(17):1304-1312

Montgomery, G. H., David, D., Winkel, G., Silverstein, J. H., Bovbjerg, D. H. (2002). The Effectiveness of Adjunctive Hypnosis with Surgical Patients: A Meta-Analysis. Anesthesia & Analgesia. 94(6), 1639-1645.

Montgomery, G. H., Durham, K. N., & Redd, W. H. (2000). A meta-analysis of hypnotically induced analgesia: How effective is hypnosis? International Journal of Clinical and Experimental Hypnosis, 48, 138-153.

Patterson D. R., Jensen M. (2003). Hypnosis and clinical pain. Psychological Bulletin. 129(4):495-521.

Peebles-Kleiger, M. J. (2000). The use of hypnosis in emergency medicine. Emergency Medicine Clinics of North America, 18(2), 327-338.

Spiegel, R. B. (2011). The Integration of Heart-Centered Hypnotherapy and Targeted Medical Hypnosis in the Surgical/Emergency Medicine Milieu. Journal of Heart-Centered Therapies, 14(2), 87-106.

Vanhaudenhuyse A, Boly M, Balteau E, Schnakers C, Moonen G, Luxen A, Lamy M, Degueldre C, Brichant J F, Maquet P, Laureys S, Faymonville Me. (2009). Pain and non-pain processing during hypnosis: a thulium-YAG event-related fMRI study. Neuroimage. 47(3):1047-1054.”